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亿博体育串子网页版

程丽君, 孙正, 孙美晨, 侯英飒

程丽君, 孙正, 孙美晨, 侯英飒. 亿博体育串子网页版[J]. 中国光学(中英文), 2024, 17(2): 444-455. doi: 10.37188/CO.2023-0114
引用本文: 程丽君, 孙正, 孙美晨, 侯英飒. 亿博体育串子网页版[J]. 中国光学(中英文), 2024, 17(2): 444-455. doi: 10.37188/CO.2023-0114
CHENG Li-jun, SUN Zheng, SUN Mei-chen, HOU Ying-sa. 亿博体育串子彩票[J]. Chinese Optics, 2024, 17(2): 444-455. doi: 10.37188/CO.2023-0114
Citation: CHENG Li-jun, SUN Zheng, SUN Mei-chen, HOU Ying-sa. 亿博体育串子彩票[J]. Chinese Optics, 2024, 17(2): 444-455. doi: 10.37188/CO.2023-0114

亿博体育串子网页版

doi: 10.37188/CO.2023-0114
基金项目:国家自然科学基金资助项目(No. 62071181)
详细信息
    作者简介:

    孙 正(1977—),女,河北保定人,博士,教授,硕士生导师,1999年、2004年于天津大学分别获得工学学士和工学博士学位,主要从事多模态成像技术、图像重建和反问题求解等的研究。E-mail:[email protected]

  • 中图分类号:TP391

亿博体育串子彩票

Funds:Supported by National Natural Science Foundation of China (No. 62071181)
More Information
  • 摘要:

    在光声层析成像(photoacoustic tomography,PAT)时,不均匀光通量分布、组织复杂的光学和声学特性以及超声探测器的非理想特性等因素会导致重建图像质量下降。本文考虑不均匀光通量、非定常声速、超声探测器的空间脉冲响应和电脉冲响应、有限角度扫描和稀疏采样等因素的影响,建立了前向成像模型。通过交替优化求解成像模型的逆问题,实现光吸收能量分布图和声速分布图的同时重建。仿真、仿体和在体实验结果表明,与反投影法、时间反演法和短滞后空间相干法相比,该方法重建图像的结构相似度和峰值信噪比可分别提高约83%、56%、22%和80%、68%、58%。由上述结果可知,对非理想成像场景采用该方法重建的图像质量有显著提高。

  • 图 1 数值仿体的横截面几何结构

    Figure 1. Cross-sectional geometry structure of numerical phantoms

    图 2 仿体的实物照片

    Figure 2. Physical photo of phantoms

    图 3 活体小鼠光声层析成像实验系统示意图

    Figure 3. Schematic diagram of PAT experimental setup for in vivo mice

    图 4 根据全角度密集采样的仿真光声信号重建的图像及其评价指标。(a)光吸收能量分布图;(b)声速分布图;(c)评价指标

    Figure 4. Reconstructed distribution maps and their evaluation metrics based on simulated photoacoustic signals that are densely-sampled and collected at a full-angle. (a) AOED distribution maps; (b) SoS distribution; (c) evaluation metrics

    图 5 根据有限角度稀疏采样仿真光声信号重建的光吸收能量分布图及其评价指标。(a) 重建图像;(b) 评价指标

    Figure 5. Results of images reconstructed from limited-view sparse sampling simulated data and their evaluation metrics. (a) Reconstructed images; (b) evaluation metrics

    图 6 仿体图像重建结果及评价指标。(a) 光吸收能量分布图;(b) 声速分布图;(c) 评价指标

    Figure 6. Reconstructed distribution maps and their evaluation metrics of phantoms. (a) AOED distribution map; (b) SoS distribution map; (c) evaluation metrics

    图 7 小鼠胸腹切片图像重建结果及评价指标。(a) 光吸收能量分布图;(b) 声速分布图;(c) 光吸收能量分布图评价指标

    Figure 7. Reconstructed thoracic and abdominal slice images of in vivo mice and evaluation metrics. (a) AOED distribution map; (b) SoS distribution map; (c) evaluation metrics of distribution map

    图 8 采用不同迭代初始值时的重建图像和迭代次数。 (a) 重建图像;(b) 重建模型1中不同位置处的AOED所需的迭代次数

    Figure 8. Reconstructed distribution maps and the number of iterations with different iterative initial values. (a) Reconstructed images; (b) number of iterations required for AOED at different locations in the reconstructed model 1

    图 9 采用不同优化算法重建的AOED分布图及其评价指标。(a) 重建图像;(b) 评价指标

    Figure 9. AOED images reconstructed using different optimization algorithms and their evaluation metrics. (a) Reconstructed images; (b) evaluation metrics

    图 10 不同固定声速条件下,根据仿真光声信号重建的AOED分布图和评价指标。(a) 重建图像;(b) 评价指标

    Figure 10. Reconstructed AOED images and evaluation metrics from simulated data using different fixed speed of sound. (a) Reconstructed images; (b) evaluation metrics

    图 11 优化光通量对重建图像质量的影响。 (a) 重建的AOED图像;(b) 评价指标

    Figure 11. Effect of optimized luminous flux on reconstructed image quality. (a) Reconstructed AOED image; (b) evaluation metrics

    图 12 采用不同的考虑超声探测器响应的方法重建的光吸收能量分布图和评价指标。(a) 重建图像;(b) 评价指标

    Figure 12. Images reconstructed by different methods that considering the response of ultrasonic detectors and their evaluation metrics. (a) Reconstructed images; (b) evaluation metrics.

    表  1 数值仿真模型的组织特性参数

    Table  1. Tissue property parameters of numerical phantoms

    组织
    名称
    组织
    成分
    折射率 吸收系数
    (cm‒1)
    散射系数
    (cm‒1)
    各向异
    性因子
    声速
    (m/s)
    密度
    (kg/L)
    心脏 肌肉组织 1.37 0.78 132 0.96 1580 1.060
    肌肉组织 1.37 0.72 114 0.95 1561 1.043
    结缔组织 1.36 0.76 205 0.90 1560 1.050
    肝脏 肌肉组织 1.37 0.75 103 0.91 1595 1.060
    胸骨 钙质 1.37 0.05 150 0.96 1580 1.050
    下载: 导出CSV
  • [1] YAO J J, WANG L V. Recent progress in photoacoustic molecular imaging[J]. Current Opinion in Chemical Biology, 2018, 45: 104-112. doi: 10.1016/j.cbpa.2018.03.016
    [2] 孙正, 王新宇. 深度学习在光声成像中的应用现状[J]. 计算机科学,2020,47(6A):148-152,156.

    SUN ZH, WANG X Y. Application of deep learning in photoacoustic imaging[J]. Computer Science, 2020, 47(6A): 148-152,156. (in Chinese).
    [3] COX B T, LAUFER J G, BEARD P C, et al. Quantitative spectroscopic photoacoustic imaging: a review[J]. Journal of Biomedical Optics, 2012, 17(6): 061202. doi: 10.1117/1.JBO.17.6.061202
    [4] JAVAHERIAN A, HOLMAN S. Direct quantitative photoacoustic tomography for realistic acoustic media[J]. Inverse Problems, 2019, 35(8): 084004. doi: 10.1088/1361-6420/ab091e
    [5] XU M H, WANG L V. Universal back-projection algorithm for photoacoustic computed tomography[J]. Proceedings of SPIE, 2005, 5697: 251-254. doi: 10.1117/12.589146
    [6] SUN ZH, HAN D D, YUAN Y. 2-D image reconstruction of photoacoustic endoscopic imaging based on time-reversal[J]. Computers in Biology and Medicine, 2016, 76: 60-68. doi: 10.1016/j.compbiomed.2016.06.028
    [7] SHAN H M, WIEDEMAN C, WANG G, et al. Simultaneous reconstruction of the initial pressure and sound speed in photoacoustic tomography using a deep-learning approach[J]. Proceedings of SPIE, 2019, 11105: 1110504.
    [8] LOU Y, WANG K, ORAEVSKY A A, et al. Impact of nonstationary optical illumination on image reconstruction in optoacoustic tomography[J]. Journal of the Optical Society of America A, 2016, 33(12): 2333-2347. doi: 10.1364/JOSAA.33.002333
    [9] 孟琪, 孙正. 生物光声层析成像中不均匀和不稳定照明解决方法[J]. 中国光学,2021,14(2):307-319. doi: 10.37188/CO.2020-0142

    MENG Q, SUN ZH. Solutions to inhomogeneous and unstable illumination in biological photoacoustic tomography[J]. Chinese Optics, 2021, 14(2): 307-319. (in Chinese). doi: 10.37188/CO.2020-0142
    [10] CHO M H, KANG L H, KIM J S, et al. An efficient sound speed estimation method to enhance image resolution in ultrasound imaging[J]. Ultrasonics, 2009, 49(8): 774-778. doi: 10.1016/j.ultras.2009.06.005
    [11] NAPOLITANO D, CHOU C H, MCLAUGHLIN G, et al. Sound speed correction in ultrasound imaging[J]. Ultrasonics, 2006, 44 Suppl: e43-e46.
    [12] PETROSYAN T, THEODOROU M, BAMBER J, et al. Rapid scanning wide-field clutter elimination in epi-optoacoustic imaging using comb LOVIT[J]. Photoacoustics, 2018, 10: 20-30. doi: 10.1016/j.pacs.2018.02.001
    [13] LEDIJU BELL M A, KUO N, SONG D Y, et al. Short-lag spatial coherence beamforming of photoacoustic images for enhanced visualization of prostate brachytherapy seeds[J]. Biomedical Optics Express, 2013, 4(10): 1964-1977. doi: 10.1364/BOE.4.001964
    [14] NGUYEN H N Y, HUSSAIN A, STEENBERGEN W. Reflection artifact identification in photoacoustic imaging using multi-wavelength excitation[J]. Biomedical Optics Express, 2018, 9(10): 4613-4630. doi: 10.1364/BOE.9.004613
    [15] 孙正, 闫向阳. 采用稀疏测量数据的有限角度光声层析成像的研究进展[J]. 声学技术,2020,39(1):1-10. doi: 10.16300/j.cnki.1000-3630.2020.01.001

    SUN ZH, YAN X Y. Progress of limited-view photoacoustic tomography imaging based on sparse measurement[J]. Technical Acoustics, 2020, 39(1): 1-10. (in Chinese). doi: 10.16300/j.cnki.1000-3630.2020.01.001
    [16] LI C H, WANG L V. Photoacoustic tomography and sensing in biomedicine[J]. Physics in Medicine & Biology, 2009, 54(19): R59-R97.
    [17] HOCHULI R, POWELL S, ARRIDGE S, et al. Forward and adjoint radiance Monte Carlo models for quantitative photoacoustic imaging[J]. Proceedings of SPIE, 2015, 9323: 93231P.
    [18] MOHAMMADI L, BEHNAM H, TAVAKKOLI J, et al. Skull’s photoacoustic attenuation and dispersion modeling with deterministic ray-tracing: towards real-time aberration correction[J]. Sensors, 2019, 19(2): 345. doi: 10.3390/s19020345
    [19] WANG K, ERMILOV S A, SU R, et al. An imaging model incorporating ultrasonic transducer properties for three-dimensional optoacoustic tomography[J]. IEEE Transactions on Medical Imaging, 2011, 30(2): 203-214. doi: 10.1109/TMI.2010.2072514
    [20] LIU D C, NOCEDAL J. On the limited memory BFGS method for large scale optimization[J]. Mathematical Programming, 1989, 45(1-3): 503-528. doi: 10.1007/BF01589116
    [21] BECK A, TEBOULLE M. A fast iterative shrinkage-thresholding algorithm for linear inverse problems[J]. SIAM Journal on Imaging Sciences, 2009, 2(1): 183-202. doi: 10.1137/080716542
    [22] HIRAKAWA M, NAGAKUBO D, KANZLER B, et al. Fundamental parameters of the developing thymic epithelium in the mouse[J]. Scientific Reports, 2018, 8(1): 11095. doi: 10.1038/s41598-018-29460-0
    [23] LU T, WANG Y H, LI J, et al. Full-frequency correction of spatial impulse response in back-projection scheme using space-variant filtering for optoacoustic mesoscopy[J]. Photoacoustics, 2020, 19: 100193. doi: 10.1016/j.pacs.2020.100193
    [24] SHENG Q W, WANG K, MATTHEWS T P, et al. A constrained variable projection reconstruction method for photoacoustic computed tomography without accurate knowledge of transducer responses[J]. IEEE Transactions on Medical Imaging, 2015, 34(12): 2443-2458. doi: 10.1109/TMI.2015.2437356
    [25] ZANGERL G, MOON S, HALTMEIER M, et al. Photoacoustic tomography with direction dependent data: an exact series reconstruction approach[J]. Inverse Problems, 2019, 35(11): 114005. doi: 10.1088/1361-6420/ab2a30
    [26] LI M L, WANG L V. A study of reconstruction in photoacoustic tomography with a focused transducer[J]. Proceedings of SPIE, 2007, 6437: 64371E.
    [27] GAVIN H P. The Levenberg-Marquardt algorithm for nonlinear least squares curve-fitting problems[D]. Durham: Duke University, 2019: 1-19.
    [28] 王倩, 蔡伟伟, 陶波. 基于层析成像的激光强度分布测量方法[J]. 中国光学(中英文),2023,16(4):743-752.

    WANG Q, CAI W W, TAO B. Laser intensity distribution measurement method based on tomographic imaging[J]. Chinese Optics, 2023, 16(4): 743-752. (in Chinese)
    [29] HELOU E S, ZIBETTI M V W, HERMAN G T. Fast proximal gradient methods for nonsmooth convex optimization for tomographic image reconstruction[J]. Sensing and Imaging, 2020, 21(1): 45. doi: 10.1007/s11220-020-00309-z
    [30] BECK A, TEBOULLE M. Fast gradient-based algorithms for constrained total variation image denoising and deblurring problems[J]. IEEE Transactions on Image Processing, 2009, 18(11): 2419-2434. doi: 10.1109/TIP.2009.2028250
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  • 收稿日期: 2023-07-22
  • 修回日期: 2023-08-24
  • 网络出版日期: 2023-11-06

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